Use of lithium hexafluoroisopropoxide as a mild base for Horner-Wadsworth-Emmons olefination of epimerizable aldehydes.
نویسندگان
چکیده
[reaction: see text] The weak base lithium 1,1,1,3,3,3-hexafluoroisopropoxide (LiHFI) is shown to be highly effective as a reagent for intermolecular Horner-Wadsworth-Emmons (HWE) olefination of epimerizable aldehydes with trimethyl phosphonoacetate, affording products with little or no epimerization and notably high E-selectivity.
منابع مشابه
Organocatalytic stereoselective synthesis of passifloricin A.
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ورودعنوان ژورنال:
- Organic letters
دوره 7 19 شماره
صفحات -
تاریخ انتشار 2005